Department of Pharmaceutical Health Sciences

25) Kai H., Genes regulating the bitterness constituents of Cucurbitaceae plants, Farumashia, 53 (2017) 920.

24) Kai H., Kinoshita K., Harada H., Uesawa Y., Maeda A., Suzuki R., Okada Y., Takahashi K., Matsuno K.: Establishment of a direct-injection electron ionization-mass spectrometry metabolomics method and its application to lichen profiling, Anal Chem, 89 (2017) 6408-6414.

23) Baba M., Fukuda E., Uesawa Y., Kai H., Matsuno K., Okada Y.: Application of Mixture Analysis to Crude Materials from Natural Resources (V): Discrimination of Glycyrrhiza uralensis and glabra by EI mass spectrometry, Nat Prod Commun, 12 (2017) 27-29.

22) Kai H., Kinoshita K., Uesawa Y., Harada H., Maeda A., Okada Y., Takahashi K., Matsuno K.: Identification of lichen species using EI-MS (2nd Report), Lichenology, 15 (2016) 117. (Proceeding)

21) Hagiwara A., Hidaka M., Takeda S., Yoshida H., Kai H., Sugita C., Watanabe W., Kurokawa M. :Anti-Allergic Action of Aqueous Extract of Moringa oleifera Lam. Leaves in Mice, European J Med Plants, 16 (2016) 1-10.

20) Kurokawa M., Wadhwani A., Kai H., Hidaka M., Yoshida H., Sugita C., Watanabe W., Matsuno K., Hagiwara A. :Activation of Cellular Immunity in Herpes Simplex Virus Type 1-Infected Mice by the Oral Administration of Aqueous Extract of Moringa oleifera Lam. Leaves, Phytother Res, 30 (2016) 797-804.

19) Kai H., Maeda A., Uesawa Y., Okada Y., Morishita K., Matsuno K. :Search for Bioactive Components from Ephedra Species against Adult T-cell Leukemia using Electron Ionization (EI)-MS- and NMR-based Metabolomics, Planta Medica, 82 (2016) SL38, DOI: 10.1055/s-0036-1596145. (Proceeding)

18) Kai H., Matsuno K.: Assessment of the Effect of Arbutin Isomers and Kojic Acid on Melanin Production, Tyrosinase Activity, and Tyrosinase Expression in B16-4A5 and HMV-II Melanoma Cells. Planta Medica Letters, 2, (2015), 39-41.

17) Kai H., Maeda A., Nagatomo A., Tahara N., Koura S., Matsuno K.: Ursolic acid and 12-O-methylcarnosic acid from the leaves of Rosmarinus officinalis L. suppressed melanin production with downregulation of tyrosinase expression in HMV-II melanoma cells. Planta Medica, 81, (2015), 3-11.（Proceeding）

16) Suzuki R., Kai H., Uesawa Y., Matsuno K., Okada Y., Shirataki Y.: Electron Ionization Mass Spectrometry-based Metabolomics Studies of Sophora flavescens can Identify the Geographical Origin of Root Samples. Natural Product Communications, 11, (2016), 73-75.

15) Kai H., Kinoshita K., Harada H., Maeda A., Okada Y., Takahashi K., Matsuno K.: Identification of lichen species (e.g. Cladonia krempelhuberi) used by EI-MS and ¹H-NMR.. Lichenology, 14, (2016), 174.（Proceeding）

14) Kurokawa M., Wadhwani A., Kai H., Hidaka M., Yoshida H., Sugita C., Watanabe W., Matsuno K., Hagiwara A.: Activation of Cellular Immunity in Herpes Simplex Virus Type 1-Infected Mice by the Oral Administration of Aqueous Extract of Moringa oleifera Lam. Leaves. Phytotherapy Research, in press.

13) Kai H., Akamatsu E., Torii E., Kodama H., Yukizaki C., Akagi I., Ino H., Sakakibara Y., Suiko M., Yamamoto I., Okayama A., Morishita K., Kataoka H., Matsuno K.: Identification of a Bioactive Compound against Adult T-cell Leukaemia from Bitter Gourd Seeds. Plants, 3, (2014), 18-26.

12) Kai H., Fuse T., Kunitake H., Morishita K., Matsuno K.: Comparison of Cultivars and Seasonal Variation in Blueberry (Vaccinium Species) Leaf Extract on Adult T-Cell Leukemia Cell Line Growth Suppression. Medicines, 1, (2014), 3-11.

11) Kai H, Obuchi M, Yoshida H, Watanabe W, Tsutsumi S, Park YK, Matsuno K, Yasukawa K, Kurokawa M.: In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08). J Funct Foods, 8, (2014), 214-223.

10) Shimizu T., Sawamura R., Kim K. H., Kim K. H., Lee S. H., Lee Y. S., Kim T. G., Kai H., Yoshida H., Watanabe W., Matsuno K., Shiraki K. and Kurokawa M.: Efficacy of Korean traditional medicines against influenza virus infection in mice and their modes of anti-influenza virus action. J Trad Med., 28, 115-127 (2011).

9) Shimizu T., Takeshita Y., Takamori Y., Kai H., Sawamura R., Yoshida H., Watanabe W., Tsutsumi A., Park Y.K., Yasukawa K., Matsuno K., Shiraki K. and Kurokawa M.: Efficacy of brazilian propolis against herpes simplex virus type 1 infection in mice and their modes of antiherpetic efficacies. Evid Based Complement Alternat Med., 2011, 976196 (2011).

8) Kai H., Akamatsu E., Torii E., Kodama H., Yukizaki C., Sakakibara Y., Suiko M., Morishita K., Kataoka H. and Matsuno K.: Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines. J Nat Med., 65, 651-655 (2011).

7) Nakajima T., Matsuno K., Matsushita M., Matsushita T., Severe lead contanimation among children of samurai families in Edo period in JapanPlacental transfer of melamine and its effects on rat dams and fetuses. J. Archaerological Science. 38, 23–28 (2011).

6) Nakajima T., Matsuno K., Matsushita M., Matsushita T.:Severe lead contanimation among children of samurai families in Edo period in Japan. J. Archaerological Science., 38: 23-28 (2011).

5) Jingbin W., Ndong M., Kai H., Matsuno K., Kayama F.: Placental transfer of melamine and its effects on rat dams and fetuses. Food Chem Toxicol., 48: 1791-1795 (2010).

4) Takami Y., Uto H., Takeshita M., Kai H., Akamatsu E., Moriuchi A., Hasegawa S., Oketani M., Ido A., Kataoka H. and Tsubouchi H.: Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90. Hepatol Res., 40: 337-345 (2010).

3) Takahashi N., Yoshida Y., Sugiura T., Matsuno K., Fujino, A. and Yamashita U.: Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro. Int. Immunopharmacol., 9, (2009), 508-513.

2) Kai H., Baba M. and Okuyama T.: Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression. Planta Med, 74, (2008), 1785-1788.

1) Baba M., Sumi S., Iwasaki N., Kai H., Sakano (nee Komiya) M., Okada Y. and Okuyama T.: Studies of the Egyptian Traditional Folk Medicines. IV. New Isoflavonoid Isolated from Egyptian Licorice. Heterocycles, 75, (2008), 3085-3089.

2) Kai H. (head)： JSPS KAKENHI , Grant-in-Aid for Young Scientists (B), Grant Number JP：17K15474

1) Matsuno K. (division)： JSPS KAKENHI , Grant-in-Aid for Scientific Research (C), Grant Number JP：22580141

4) Kai H., Maeda A., Uesawa Y., Okada Y., Morishita K., Matsuno K. :Search for Bioactive Components from Ephedra Species against Adult T-cell Leukemia using Electron Ionization (EI)-MS- and NMR-based Metabolomics, 9th Joint Natural Products Conference, 2016.7, Copenhagen, Denmark.

3) Kai H., Maeda A., Nagatomo A., Tahara N., Koura S. and Matsuno K.: Ursolic acid and 12-O-methylcarnosic acid from the leaves of Rosmarinus officinalis L. suppressed melanin production with downregulation of tyrosinase expression on HMV-II melanoma cells. The 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2015. 8, Budapest, Hungary.

2) Matsuoka, S., Hanada, A. Kano, H., Matsuno, K., Kai, H., Hirano, T.: Genistein protects liver cells from acetaminophen-induced hepatotoxicity. The 6th International Symposium on Alcohlic Liver and Pancreatic Diseases and Chirrosis (ISALPD/C)C, 2011.10, Fukuoka, Japan

1) Kai H., Akamatsu E., Torii E., Iwata T., Morinaga I., Kodama H., Morinaga H., Yamamoto I., Sakai M., Yukizaki C., Sakakibara Y., Suiko M., Okayama A., Kataoka H. and Matsuno K.: Inhibitory Effects of the Seeds from Momordica Charantia on Proliferation of Adult T-cell Leukemia. The JSPS 3rd Medicinal Chemistry Seminar of Asia/Africa Science Platform Program and The 2nd International Seminar of Meiji Pharmaceutical University Asia/Africa Center for Drug Discovery, 2009. 1, Tokyo, Japan.